A new, double-blind, placebo-controlled clinical study has demonstrated that the water-soluble form of Nektium’s Zynamite can significantly enhance cognitive performance in beverages and beyond.
Zynamite is a patented mango leaf extract produced in Spain by Nektium, using a proprietary process that ensures the highest levels of purity and efficacy.
Studies have already shown that the award-winning mangiferin ingredient provides fast-acting, non-stim mental energy without side effects, and it has been used successfully in a range of supplements.
However, mangiferin’s naturally low solubility has limited its potential for energy drinks and other beverage applications. Additionally, higher dosages were previously required due to the impact of low solubility on bioavailability.
Using in-house proprietary smart delivery technology, Nektium recently developed a water-soluble version of Zynamite. It has a neutral taste and is optimised for use in beverage applications, maintaining the level of mangiferin absorbed to ensure its efficacy even at low dosages.
New research published in Pharmaceuticals has confirmed that the water-soluble version of Zynamite (Zynamite S) maintained its beneficial effects on cognitive performance and mood at a lower dose.
A recent study on university students demonstrated that participants taking a single dose of Zynamite showed significant improvements in performance across a wide range of tests, including processing speed, complex task handling, and mental flexibility.
The randomised, double-blind, placebo-controlled crossover study evaluated the efficacy of a single dose of water-soluble Zynamite on comprehensive cognitive function, mental energy, and mood. The study featured 120 healthy university students, who were each given 100mg or 150mg of Zynamite, standardised to contain at least 60 percent mangiferin, or a placebo.
A series of cognitive performance tests were evaluated, including executive functions with the Trail Making Test (TMT), processing speed with the Digit Symbol Substitution Test (DSST), and selective attention with the Stroop Colour and Word Test. Assessments were made before taking the product and then at 30 minutes, three hours, and five hours after consumption.
“Mangiferin’s low solubility has always presented a challenge for beverage applications. The results of this new study provide compelling scientific evidence that low dosages of our water-soluble Zynamite deliver significant improvements to cognitive function while also reducing perception of stress,” said Dr. Laura Lopez, Head of Product Research, Development and Innovation at Nektium.
Those taking Zynamite recorded superior scores in multiple areas, including confusion, depression, and overall score dimensions, compared to the placebo group.
Confusion perception was significantly reduced among those taking a 100mg dose at three hours and five hours (37.9 percent and 61.48 percent), while general mood improved around 20 percent at three hours for both doses.
Tension scores also improved by 35.4 percent in the 100mg group and by 52.3 percent in the 150mg group at five hours post-consumption.
“Zynamite is an experiential ingredient that delivers fast-acting support for clarity, focus, and concentration for up to five hours. It’s perfectly suited to today’s busy consumers who want natural alternatives to sugary and caffeinated energy drinks,” said Bruno Berheide, Nektium’s Commercial and Partnership Director.
“From working professionals to stressed-out students to e-gamers, it helps them stay sharp and keep their cool with just a single dose.”
Zynamite has already been used successfully in many supplements targeting sports and nootropic applications. The water-soluble version now opens up new possibilities. It is easy to integrate at a low dose in a wide range of products, including RTDs, shots, and shakes, as well as gummies and powder sticks.
